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Fig. 1 | Journal of Neurodevelopmental Disorders

Fig. 1

From: Spatiotemporal development of spinal neuronal and glial populations in the Ts65Dn mouse model of Down syndrome

Fig. 1

Cellular populations at E10.5 in the Ts65Dn spinal cord. A A representative confocal image of a cross section of an E10.5 spinal cord from a euploid mice stained for Isl1, OLIG2, NKX6.1, and NKX2.2. A′ An inset showing a magnified view of the OLIG2 progenitor domain in euploid and Ts65Dn spinal cords. B Average cell density of trisomic animals compared to euploid controls. Trisomic animals show a significant increase of Olig2+ pMN progenitor cells as well as a trend towards an increase in the number of fated motor neurons (Olig2+/Isl1+) and oligodendrocyte precursor cells (OPCs) (Olig2+/Nkx2.2+). C Along with an increase in Olig2+ density, the width of the Olig2+ pMN domain is significantly increased. D We also assessed changes in proliferation of the progenitors between genotypes and found E no difference in PH3+ cells in total or changes in their distribution measured F laterally from the lumen or G from the ventral edge (n = 6 euploid and 6 Ts65Dn; *p < 0.05, #p < 0.2)

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