Skip to main content


Fig. 2 | Journal of Neurodevelopmental Disorders

Fig. 2

From: Spatiotemporal development of spinal neuronal and glial populations in the Ts65Dn mouse model of Down syndrome

Fig. 2

Expression and population analyses at E12.5 in the Ts65Dn spinal cord. A Representative confocal images of cross sections of an E12.5 spinal cord stained for Isl1, Olig2, Pax6, B Nkx2.2, and C Nkx6.1. A′ An inset showing a comparison of OLIG2, ISL1, and PAX6 staining in euploid and Ts65Dn spinal cords. D qRT-PCR analysis shows a significant increase in expression levels of Hb9 and Olig2 in the trisomic spinal cords (n = 3 euploid and 3 Ts65Dn; *p < 0.05). E At E12.5, there is no significant difference in the number of Olig2+ cells or in F the size of the various progenitor domains between euploid and trisomic individuals. G Trisomic animals show a significant increase in the number of Isl1+ migrating motor neurons as well as a significant increase in the number of abventricular Pax6+ inhibitory interneurons and Nkx2.2+ excitatory interneurons (n = 4 euploid and 5 Ts65Dn; *p < 0.05, **p < 0.01, ***p < 0.001)

Back to article page