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Fig. 5 | Journal of Neurodevelopmental Disorders

Fig. 5

From: Spatiotemporal development of spinal neuronal and glial populations in the Ts65Dn mouse model of Down syndrome

Fig. 5

Oligodendrocyte maturation analyses in the DCST and LF. Representative confocal images of the a dorsal corticospinal tract (DCST) and b lateral funiculus (LF) stained with Olig2+ to mark all oligodendrocyte lineage cells and CC1+ and Ng2+ to mark mature and immature oligodendrocytes, respectively. In the DCST at c P30 and e P60, there is a significantly smaller percentage of mature CC1+ oligodendrocytes in the trisomic animals. g By 10–11 months, this change in maturation is no longer present, but there are significantly fewer oligodendrocytes in total in the trisomic animals. d, f, h In the LF at all ages analyzed, there is a significantly higher percentage of CC1+ mature oligodendrocytes in the trisomic animals (P30 n = 3 euploid and 3 Ts65Dn; P60 n = 4 euploid and 4 Ts65Dn; 10–11 months n = 4 euploid and 6 Ts65Dn; *p < 0.05)

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