Fig. 1

Specific cytokines and chemokines are significantly elevated in IUGR brains during development. Inflammatory cytokines and chemokines were measured by Luminex assay in total brain lysate at a e19, b PD1, c PD7, and d PD14. Data are expressed as fold change compared with controls (n = 4 measurements/age/group). Those with a statistically significant difference at a minimum of one time point are shown. *Significant difference versus control [a MCP 1: P < 0.001; b IL-10: P = 0.004, IL-18: P = 0.021, eotaxin: P = 0.007; c IL-4: P = 0.028, IL-5: P = 0.019, IL-6: P = 0.020, eotaxin: P = 0.038, Gro-KC: P = 0.028, leptin: P = 0.032; d IL-4: P = 0.011 m IL-5: P = 0.010, eotaxin: P = 0.010, leptin: P = 0.012, two-tailed T test]; ND, undetectable; white bars, control; gray bars, IUGR