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Fig. 5 | Journal of Neurodevelopmental Disorders

Fig. 5

From: Reducing Th2 inflammation through neutralizing IL-4 antibody rescues myelination in IUGR rat brain

Fig. 5

Injection of IL-4 blocking antibody increases numbers of oligodendrocytes in IUGR to control levels. a Shown are representative sections of the P14 corpus callosum from control and IUGR pups treated with anti-IL-4 or PBS labeled with antibody to PLP. DAPI, blue; PLP, red. Arrows indicate areas of patchy myelin loss in IUGR animals treated with PBS which are not evident in anti-IL-4-treated IUGRs. b Shown are representative sections of the P14 corpus callosum from control and IUGR pups treated with anti-IL-4 or PBS stained with antibody to with CC-1, which labels the cell body of mature oligodendrocytes. DAPI, blue; CC1, green. c Quantification of CC1+ cells per ROI in the corpus callosum demonstrates that the PBS-treated IUGRs have significantly fewer oligodendrocytes than control or anti-IL-4-treated IUGR section (n = 3 rats per condition). *Significant difference at P = 0.017 versus control PBS, two-tailed T test. **Significant difference at P = 0.05 versus IUGR PBS, two-tailed T test

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