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Fig. 6 | Journal of Neurodevelopmental Disorders

Fig. 6

From: Guanfacine treatment improves ADHD phenotypes of impulsivity and hyperactivity in a neurofibromatosis type 1 mouse model

Fig. 6

Guanfacine (GUAN, 0.3 mg/kg) decreases impulsive choice in Nf1+/− mice in the delay discounting test (DDT). Graphs depict the effects of GUAN on a the number of small reinforcements chosen during a DDT task in a t-maze and b the number of days the mice took to reach criterion prior to the initiation of the delay. *p < 0.05 compared to wild-type (WT) within the same treatment. #p < 0.05 compared to vehicle (VEH) within the same genotype. All data reported as mean + S.E.M. Black-filled bars represent WT mice treated with VEH. Green-filled bars represent Nf1+/− mice treated with VEH. Gray-filled bars with pattern represent WT mice treated with GUAN. Green-filled bars with pattern represent Nf1+/− mice treated with GUAN

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