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Table 2 Top 5 most significantly over-represented GO terms and KEGG pathways represented by annotated genes of transcripts differentially expressed in the ethanol, stress, or ethanol + stress groups compared to control (p < 0.01)

From: Hippocampal transcriptome analysis following maternal separation implicates altered RNA processing in a mouse model of fetal alcohol spectrum disorder

EthanolStressEthanol + stress
Termp valueTermp valueTermp value
Molecular function
 Haptoglobin binding1.64E−09 Protein binding8.30E−05 Haptoglobin binding6.68E−09
 Oxygen binding5.48E−07 Binding1.28E−04 Oxygen binding2.17E−06
 Hemoglobin alpha binding1.97E−06 Protein serine/threonine/tyrosine kinase activity0.001 Hemoglobin alpha binding4.56E−06
 Hemoglobin binding1.69E−05 Transferase activity0.002 Hemoglobin binding3.89E−05
 Protein binding1.84E−05 Catalytic activity, acting on a protein0.002 Oxygen carrier activity9.20E−05
Biological process
 Regulation of alternative mRNA splicing, via spliceosome3.75E−07 Microtubule cytoskeleton organization involved in establishment of planar polarity8.64E−05 Macromolecule modification2.34E−04
 Regulation of mRNA splicing, via spliceosome8.29E−07 Golgi organization4.85E−04 Response to chemical2.37E−04
 Alternative mRNA splicing, via spliceosome1.25E−06 Endomembrane system organization0.001 Response to temperature stimulus2.39E−04
 Regulation of RNA splicing8.49E−06 Embryo development0.001 Cellular protein modification process2.55E−04
 Regulation of mRNA processing1.01E−05 Organonitrogen compound metabolic process0.001 Protein modification process2.55E−04
Cellular component
 Hemoglobin complex1.64E−09 Intracellular part7.05E−05 Hemoglobin complex6.68E−09
 Haptoglobin-hemoglobin complex3.67E−09 Intracellular9.42E−05 Haptoglobin-hemoglobin complex1.49E−08
 Synapse2.09E−05 Organelle part1.43E−04 Intracellular part1.39E−04
 Synapse part2.86E−05 Intracellular organelle part3.46E−04 Intracellular2.07E−04
 Postsynapse0.001 Basal cortex0.001 Cell part0.001
KEGG pathway
 African trypanosomiasis6.90E−06 Circadian entrainment0.002 African trypanosomiasis2.66E−05
 Malaria3.50E−05 Retrograde endocannabinoid signaling0.009 Malaria1.31E−04
 Steroid biosynthesis0.01 Glycerophospholipid metabolism0.012 Mucin type O-glycan biosynthesis0.002
 Porphyrin and chlorophyll metabolism0.028 GABAergic synapse0.012 Glycine, serine, and threonine metabolism0.008
 ECM-receptor interaction0.029 Morphine addiction0.012 Systemic lupus erythematosus0.008