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Fig. 3 | Journal of Neurodevelopmental Disorders

Fig. 3

From: Effects of a postnatal Atrx conditional knockout in neurons on autism-like behaviours in male and female mice

Fig. 3

Atrx-cKOMALE and Atrx-cKOFEMALE mice do not display stereotyped behaviours. a Percentage of marbles buried during 30-min marble burying task (twANOVA, genotype, F(1, 49) = 0.0003, p = 0.985; twANOVA, sex, F(1, 49) = 1.038, p = 0.313; twANOVA, interaction, F(1, 49) = 4.132, *p = 0.047). b Total time grooming during 30-min water-induced grooming task (twANOVA, genotype, F(1, 48) = 1.200, p = 0.279; twANOVA, sex, F(1, 48) = 0.268, p = 0.607). c, d Amount of time spent grooming over 5-min intervals during water-induced grooming task (twANOVA, males, F(1, 44) = 2.386, p = 0.125; twANOVA, females, F(1, 44) = 0.562, p = 0.455). e Total number of vertical episodes during 120-min open-field test (twANOVA, genotype, F(1, 49) = 0.673, p = 0.416; twANOVA, sex, F(1, 49) = 18.71, ****p < 0.0001). f Number of vertical episodes over 10-min intervals during the 120-min open-field test (twANOVA, genotype, F(1, 51) = 0.866, p = 0.356; twANOVA, sex, F(1, 51) = 19.19, ****p < 0.0001; mc, *p < 0.05, **p < 0.01). Atrx-cKOMALE: n = 10, CtrlMALE: n = 17, Atrx-cKOFEMALE: n = 13, CtrlFEMALE: n = 13. Error bars: ±SEM

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