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Fig. 4 | Journal of Neurodevelopmental Disorders

Fig. 4

From: Effects of a postnatal Atrx conditional knockout in neurons on autism-like behaviours in male and female mice

Fig. 4

Acoustic startle response of Atrx-cKO mice is typical. a, b Quantification of startle responses (recorded in millivolts) to 50 “pulse only” trials (twANOVA, genotype, F(1, 48) = 0.084, p = 0.773; twANOVA, sex, F(1, 48) = 5.555, *p = 0.023). c, d Averaged pre-pulse inhibition for four trial types, varying in interstimulus intervals (30 ms or 100 ms) and pre-pulse intensity (75 db or 80 db). Startle responses for these trials are expressed as a percentage of the normalized “pulse only” trial (baseline) (Student’s t test, Atrx-cKOMALE, and CtrlMALE for each trial type, p > 0.05; Student’s t test, Atrx-cKOFEMALE and CtrlFEMALE for each trial type, p > 0.05). Atrx-cKOMALE: n = 10, CtrlMALE: n = 17, Atrx-cKOFEMALE: n = 11, CtrlFEMALE: n = 12. Error bars: ±SEM

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