TY - JOUR AU - Wu, Rui-Ni AU - Hung, Wei-Chen AU - Chen, Ching-Tsuey AU - Tsai, Li-Ping AU - Lai, Wen-Sung AU - Min, Ming-Yuan AU - Wong, Shi-Bing PY - 2020 DA - 2020/07/29 TI - Firing activity of locus coeruleus noradrenergic neurons decreases in necdin-deficient mice, an animal model of Prader–Willi syndrome JO - Journal of Neurodevelopmental Disorders SP - 21 VL - 12 IS - 1 AB - Prader–Willi syndrome (PWS) is a neurodevelopmental disorder characterized by multiple respiratory, cognitive, endocrine, and behavioral symptoms, such as central apnea, intellectual disabilities, exaggerated stress responses, and temper tantrums. The locus coeruleus noradrenergic system (LC-NE) modulates a diverse range of behaviors, including arousal, learning, pain modulation, and stress-induced negative affective states, which are possibly correlated with the pathogenesis of PWS phenotypes. Therefore, we evaluated the LC-NE neuronal activity of necdin-deficient mice, an animal model of PWS. SN - 1866-1955 UR - https://doi.org/10.1186/s11689-020-09323-4 DO - 10.1186/s11689-020-09323-4 ID - Wu2020 ER -