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Table 2 Comparison of clusters and factors between the feasibility study (Leclezio et al. 2018) and this study (the replication study)

From: Natural clusters of tuberous sclerosis complex (TSC)-associated neuropsychiatric disorders (TAND): new findings from the TOSCA TAND research project

Clusters and factors

Variables

Both feasibility and replication studies

Replication study

(current study)

Feasibility study

(Leclezio et al. 2018)

TAND clusters

1. Mood/anxiety

Anxiety (Banx)

Depressed mood (Bdep)

Extreme shyness (Bshy)

Sleep difficulties (Bsleep)

-

-

2. Dysregulated behavior

Mood swings (Bmood)

Aggressive outbursts (Baggr)

Temper tantrums (Btemp)

-

-

3. ASD-like

Absent or delayed language (Blang)

Repeating words or phrases (BU.lan)

Poor eye contact (Beye)

Repetitive behaviors (Brep)

Difficulties with eating (Beat)

Peer difficulties (Bp.diff)

Rigidity/inflexibility (Bflex)

Self-injury (Bs.inj)

Visuo-spatial difficulties (NPSv.spat)

4. Hyperactive/impulsive

Overactivity (Bo.act)

Impulsivity (Bimpul)

Self-injury (Bs.inj)

Rigidity/inflexibility (Bflex)

Restlessness (Brestl)

5. Neuropsychological

Difficulty paying attention (Ba.diff)

Memory difficulties (NPSmem)

Attention difficulties (NPSatt)

Dual-tasking difficulties (NPSd.task)

Executive difficulties (NPSexe)

-

Visuo-spatial difficulties (NPSdisor)

Peer difficulties (Bp.diff)

6. Scholastic

Reading difficulties (SCread)

Writing difficulties (SCwrit)

Spelling difficulties (SCspel)

Mathematics difficulties (SCmath)

Restlessness (Brestl)

Visuo-spatial difficulties (NPSv.spat)

Disorientation (NPSdisor)

-

TAND factors

1. Scholastic and Neuropsychological

Dueal-task difficulties (NPSd.task)

Executive difficulties (NPSexe)

Mathematics difficulties (SCmath)

Reading difficulties (SCread)

Writing difficulties (SCwrit)

Spelling difficulties (SCspel)

Visuo-spatial difficulties (NPSv.spat)

Memory difficulties (NPSmem)

Disorientation (NPSdisor)

Poor eye contact (Beye)

Attention difficulties (Ba.diff)

Neuropsychological attention difficulties (NPSatt)

2. ASD-like

Absent or delayed language (Blang)

Repeating words or phrases (BU.lan)

Peer difficulties (Bp.diff)

Repetitive behaviors (Brep)

Eating difficulties (Beat)

Rigidity/inflexibility (Bflex)

Visuo-spatial difficulties (NPSv.spat)

Disorientation (NPSdisor)

Self-injury (Bs.inj)

Poor eye contact (Beye)

3. Hyperactive/impulsive

Restlessness (Brestl)

Overactivity (Bo.act)

Impulsivity (Bimpul)

Self-injury (Bs.inj)

Rigidity/inflexibility (Bflex)

4. Dysregulated behavior

Aggressive outbursts (Baggr)

Temper tantrums (Btemp)

Extreme shyness (Bshy)

Anxiety (Banx)

Mood swings (Bmood)

5. Mood/anxiety

Depressed mood (Bdep)

Sleep difficulties (Bsleep)

Anxiety (Banx)

Memory difficulties (NPSmem)

Extreme shyness (Bshy)

6. Attentional

-NA-

Neuropsychological attention difficulties (NPSatt)

Attention difficulties (Ba.diff)

Mood swings (Bmood)

-NA-

  1. ASD autism spectrum disorder
  2. The columns show all TAND Checklist items included in the study and the abbreviation for each variable in parenthesis e.g. Anxiety (Banx)