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Fig. 2 | Journal of Neurodevelopmental Disorders

Fig. 2

From: Protective role of mirtazapine in adult female Mecp2+/− mice and patients with Rett syndrome

Fig. 2

Assessment of motor phenotypes and anxiety-related behaviours of 6-month-old Mecp2tm1.1Bird female mice after treatment with MTZ (10 mg/kg). a Motor learning at the horizontal bar test, measured as the change (delta value) between performance at the end and at the beginning of the treatment. b Motor learning at the dowel test, measured as the change (delta values) between performance at the end and at the beginning of the treatment. c Total travelled distance in the open field. d Scoring of the nests built by mice after 24 h in isolation. e Transient time at the rod walk test. All data are expressed as median ± interquartile range, n = 10–11 mice per each group. f Time spent in open arms in the elevated plus maze in wild-type (WT) and heterozygous (HET) mice, treated with either mirtazapine (MTZ) or vehicle (VEH). A group of untreated HET mice whose whiskers were clipped (HET-UNTw-) is also included in the graph. g Time spent in zones in the dark-light exploration test by untreated (UNT) WT and HET mice. h Number of transitions between the light and the dark zones. i Time spent in each zone in the open field by WT and HET mice after treatment with VEH. All data are expressed as median ± interquartile range, n = 7–11 mice per group. According to results of Saphiro-Wilk test, we performed either one-way ANOVA followed by Sidak’s multiple comparison test or Kruskal-Wallis test, followed by corrected Dunn’s post hoc test. Two-way ANOVA multiple selected comparisons comprehended: WT-VEH vs WT-MTZ, WT-VEH vs HET-VEH, and HET-VEH vs HET-MTZ. In order to determine an eventual genotype effect, 2-way ANOVA was performed in the open-field test. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001

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