Fig. 4

Effects of MTZ treatment on RCSS and MBAS in RTT patients. a Rett clinical severity scale (RCSS), scores before and after the treatment (or an equivalent time period when no treatment was present) for each patient are individually represented. b Comparison of RCSS delta averages between groups. c Motor behavioural assessment scale (MBAS), scores before and after the treatment (or an equivalent time period when no treatment was present) for each patient are individually represented. d Comparison of MBAS delta averages between groups. Data are expressed as either paired values (a, c) or boxplots (b, d). In all cases, according to results of Shapiro-Wilk test, we used paired Student’s t test or Wilcoxon signed rank test for comparisons between pre and post-treatment time points, while we used unpaired Student’s t test or Mann-Whitney test to compare averages between treated (n = 11) and untreated (n = 11) groups. ns: p > 0.05 (not shown); *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001