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Table 2 Dosages and duration of Mirtazapine (MTZ) treatment on patients

From: Protective role of mirtazapine in adult female Mecp2+/− mice and patients with Rett syndrome

MTZ treatment in RTT

Patient

Daily dose (mg/day)

Per kg dose (mg kg bw/day)

Treatment duration (years)

Tolerance

No. 1

7.5

0.170

2

T

No. 2

15

0.375

2

T

No. 3

7.5

1.071

2

T

No. 4

30

0.428

5

T

No. 5

30

0.806

2

T

No. 6

15

0.395

1

T

No. 7

15

0.288

2

NT

No. 8

22.5

0.625

3

T

No. 9

7.5

0.306

1

T

No. 10

15

0.288

2

T

No. 11

15

0.441

0.08

NT

No. 12

3.75

0.122

1.4

T

No. 13

3.75

0.170

1

T

No. 14

7.5

0.250

1.2

T

No. 15

7.5

0.187

0.08

NT

No. 16

15

0.273

0.5

NT

No. 17

7.5

1.970

1.4

T

No. 18

3.75

0.288

1

T

No. 19

7.5

0.115

2

T

No. 20

15

0.300

1.7

T

No. 21

7.5

0.263

1.1

T

No. 22

7.5

0.250

1.4

T

No. 23

7.5

0.166

1.2

T

No. 24

15

0.250

1.5

T

No. 25

15

0.220

1.1

T

No. 26

15

0.211

1

T

No. 27

7.5

0.227

1.2

T

No. 28

15

0.286

1

T

No. 29

15

0.214

2.4

T

No. 30

15

0.300

2.1

T

No. 31

15

0.329

5

T

No. 32

7.5

0.205

2.3

T

No. 33

7.5

0.246

2

T

No. 34

7.5

0.117

1.1

T

No. 35

7.5

0.227

1.5

T

No. 36

3.75

0.174

1

T

No. 37

7.5

0.246

2.2

T

No. 38

7.5

0.258

1.3

T

No. 39

7.5

0.246

2.2

T

No. 40

3.75

0.134

1.2

T

  1. Dosages were personalized for each patient according to clinical observations. Data are expressed as daily dose (mg/day) and per kg dose (mg/kg bw/day) of MTZ. Duration of MTZ treatment was always longer than 1 year, with four exceptions (patients Nos. 7, 11, 15, and 16), in whom an intolerance (NT) to the drug was observed. In all the other cases, MTZ treatment was well tolerated (T)