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Fig. 2 | Journal of Neurodevelopmental Disorders

Fig. 2

From: Deficits in skilled motor and auditory learning in a rat model of Rett syndrome

Fig. 2

Skilled motor learning is impaired in Mecp2 rats. a Illustration of a rat performing the lever pressing task. Rats were tasked with reaching out through a narrow slot in the cage and pressing a lever twice in rapid succession. b Representative data collected using the task, depicting a trial with a successful double press. c Mecp2 rats were significantly slower to progress though training than WT (Mecp2 n = 15, WT n = 13). d A smaller portion of Mecp2 rats completed the final stage of training within 12 weeks compared to WT rats (Mecp2 n = 15, WT n = 13). e Mecp2 rats demonstrated significant reductions in lever pressing speed, as evidenced by an increase in the inter-press interval (IPI) (Mecp2 n = 10, WT n = 13). f Additionally, Mecp2 rats completed significantly fewer trials than WT animals (Mecp2 n = 15, WT n = 13). Circles depict individual subjects. Bars represent the mean and error bars indicate SEM across rats. The asterisk (*) denotes p < 0.05 across groups

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