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Fig. 4 | Journal of Neurodevelopmental Disorders

Fig. 4

From: Long-term spatial tracking of cells affected by environmental insults

Fig. 4

Functional characteristics of RFP-positive cortical pyramidal neurons. a Representative DIC images of patch-clamp experiments conducted on upper layer cortical pyramidal neurons (top), and fluorescent images of RFP expressing neurons used for recording (bottom). b No significant differences were observed in neuronal membrane properties including: capacitance [F(2, 52) = 0.16, P = 0.85 by one-way ANOVA], input resistance [F(2, 52) = 0.077, P = 0.93], access (series) resistance [F(2, 52) = 0.09, P = 0.91], and resting potential [F(2, 24) = 0.63, P = 0.54] between RFP+, RFP−, and RFP− control neurons. c Example voltage-clamp traces depicting spontaneous excitatory post-synaptic currents (sEPSC) recorded in cortical neurons from each group in reporter transgenic mice. d No significant differences were observed in sEPSC characteristics including amplitude [F(2, 31) = 0.65, P = 0.53 by one-way ANOVA], frequency [F(2, 31) = 0.004, P = 0.99], and decay time (half-amplitude) [F(2, 31) = 0.08, P = 0.92] between groups

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