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Fig. 2 | Journal of Neurodevelopmental Disorders

Fig. 2

From: Developmental exposure to diesel exhaust upregulates transcription factor expression, decreases hippocampal neurogenesis, and alters cortical lamina organization: relevance to neurodevelopmental disorders

Fig. 2

Adult neurogenesis in the hippocampal dentate gyrus. Adult neurogenesis in the hippocampal dentate gyrus, as measured by Tbr2 immunohistochemistry. Tbr2 is expressed in intermediate progenitor cells [28, 39], and in the adult brain is a marker of newly-divided neurons in the subventricular zone (SVZ) and hippocampal subgranular zone (SGZ) [11, 39, 52, 53]. Representative images from a FA-exposed male (a) and DE-exposed male (b) are shown, with Tbr2+ cells (in green), counterstained with the nuclear stain DAPI (blue). DE exposure was associated with a significant decrease in the number of Tbr2+ cells in the SGZ in both males and females (c). Results represent the mean (± SE) of 5 mice from different litters for each experimental group (**p < 0.01; ***p < 0.001; unpaired t test with Welch’s correction)

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Journal of Neurodevelopmental Disorders

ISSN: 1866-1955

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