TY - JOUR AU - Berg, Elizabeth L. AU - Ching, Tianna M. AU - Bruun, Donald A. AU - Rivera, Josef K. AU - Careaga, Milo AU - Ellegood, Jacob AU - Lerch, Jason P. AU - Wöhr, Markus AU - Lein, Pamela J. AU - Silverman, Jill L. PY - 2020 DA - 2020/12/16 TI - Translational outcomes relevant to neurodevelopmental disorders following early life exposure of rats to chlorpyrifos JO - Journal of Neurodevelopmental Disorders SP - 40 VL - 12 IS - 1 AB - Neurodevelopmental disorders (NDDs), including intellectual disability, attention deficit hyperactivity disorder (ADHD), and autism spectrum disorder (ASD), are pervasive, lifelong disorders for which pharmacological interventions are not readily available. Substantial increases in the prevalence of NDDs over a relatively short period may not be attributed solely to genetic factors and/or improved diagnostic criteria. There is now a consensus that multiple genetic loci combined with environmental risk factors during critical periods of neurodevelopment influence NDD susceptibility and symptom severity. Organophosphorus (OP) pesticides have been identified as potential environmental risk factors. Epidemiological studies suggest that children exposed prenatally to the OP pesticide chlorpyrifos (CPF) have significant mental and motor delays and strong positive associations for the development of a clinical diagnosis of intellectual delay or disability, ADHD, or ASD. SN - 1866-1955 UR - https://doi.org/10.1186/s11689-020-09342-1 DO - 10.1186/s11689-020-09342-1 ID - Berg2020 ER -