Table 4 Adjusted (adjusted for the following covariates: child sex, month and year of birth, county, and insurance type) linear and logistic regression models estimating paths A and B of candidate mediation models
Path A Air pollutant -> immune marker | Path B Immune marker + air pollutant -> outcome | |||||||
|---|---|---|---|---|---|---|---|---|
| Â | Beta | 95% CI | p | Â | Â | OR | 95% CI | p |
NO2 -> IL-6 | − 0.05 | (− 0.08, − 0.03) | < 0.001 | NO2 + IL-6 -> ASD w/ ID | 0.99 | (0.97, 1.02) | 0.57 | |
1.11 | (1.03, 1.20) | 0.01a | ||||||
NO2 -> IL-8 | − 0.03 | (− 0.05, − 0.02) | < 0.001 | NO2 + IL-8-> ASD w/ ID | 0.99 | (0.97, 1.01) | 0.44 | |
1.09 | (0.96, 1.24) | 0.18 | ||||||
NO2 -> MCP-1 | − 0.02 | (− 0.03, − 0.01) | < 0.001 | NO2 + MCP-1-> ASD w/ ID | 0.99 | (0.97, 1.01) | 0.40 | |
1.10 | (0.89, 1.36) | 0.37 | ||||||
Ozone -> IL-8 | 0.02 | (0.01, 0.03) | < 0.001 | Ozone + IL-8-> ASD w/ ID | 1.00 | (0.99, 1.02) | 0.64 | |
1.09 | (0.96, 1.24) | 0.16 | ||||||
NO2 -> MCP-1 | − 0.02 | (− 0.02, − 0.01) | < 0.001 | NO2 + MCP-1-> ASD w/o ID | 0.99 | (0.97, 1.02) | 0.58 | |
0.77 | (0.62, 0.97) | 0.03a | ||||||
Ozone -> IL-8 | 0.02 | (0.01, 0.03) | < 0.001 | Ozone + IL-8-> ASD w/o ID | 1.00 | (0.99, 1.02) | 0.67 | |
0.88 | (0.78, 0.99) | 0.03a | ||||||
NO2 -> IL-10 | − 0.03 | (− 0.05, − 0.02) | < 0.001 | NO2 + IL-10-> ASD w/o ID | 0.99 | (0.96, 1.01) | 0.32 | |
0.98 | (0.87, 1.10) | 0.74 | ||||||
NO2 -> IL-6 | − 0.05 | (− 0.07, − 0.02) | < 0.001 | NO2 + IL-6-> ID w/o ASD | 0.99 | (0.96, 1.01) | 0.29 | |
0.97 | (0.89, 1.05) | 0.45 | ||||||
NO2 -> IL-8 | − 0.03 | (− 0.04, − 0.01) | < 0.001 | NO2 + IL-8-> ID w/o ASD | 0.99 | (0.96, 1.01) | 0.29 | |
0.94 | (0.82, 1.08) | 0.40 | ||||||
NO2 -> MCP-1 | − 0.02 | (− 0.03, − 0.01) | < 0.001 | NO2 + MCP-1-> ID w/o ASD | 0.99 | (0.96, 1.01) | 0.31 | |
0.94 | (0.74, 1.2) | 0.63 | ||||||