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Table 4 Attention-deficit/hyperactivity disorder (ADHD) medication mean doses (mg/day) in 6 months intervals, comparing individuals with ADHD with coexisting autism spectrum disorder (ASD) versus ADHD without coexisting ASD, and stratified analyses by sex, age category (adults/adolescents/children), substance use disorder (SUD), and intellectual disability (ID)

From: Medications for attention-deficit/hyperactivity disorder in individuals with or without coexisting autism spectrum disorder: analysis of data from the Swedish prescribed drug register

 

ADHD without coexisting ASD

ADHD with coexisting ASD

  
 

Number of subjects (%)

Median

Range doses (mg)

Number of subjects

Median

Range doses (mg)

Z value

p value

All, months

        

 0-6

25508 (100)

39.9

2-570

3467 (100)

35.7

2-437

-8.97

< 0.0001

 7-12

20661 (81)

35.5

1-799

2759 (80)

35.5

1-368

-6.32

< 0.0001

 13-18

18420 (72)

35.5

1-1065

2505 (72)

35.5

1-762

-4.56

< 0.0001

 19-24

17471 (68)

39.4

0.01-1058

2373 (68)

35.5

2-669

-4.46

< 0.0001

 25-30

16393 (64)

39.4

1-943

2269 (65)

35.5

1-674

-4.70

< 0.0001

 31-36

15508 (61)

41.4

1-879

2171 (63)

38.4

1-762

-3.55

0.0004

Adults, months

        

 0-6

12327 (100)

50.3

2-570

1477 (100)

42.9

2-437

-5.35

< 0.0001

 7-12

9661 (78)

52.6

1-799

1129 (76)

44.4

2-368

-3.94

< 0.0001

 13-18

8433 (68)

52.6

2-1065

1020 (69)

44.4

1-762

-4.04

< 0.0001

 19-24

7960 (65)

53.2

0.01-1058

936 (63)

47.3

2-669

-2.49

0.0047

 25-30

7435 (60)

53.2

1-943

894 (61)

46.4

1-674

-3.85

< 0.0001

 31-36

7032 (57)

53.2

1-879

840 (57)

53.2

1-762

-2.87

0.0016

Adolescents, months

        

 0-6

5922 (100)

38.4

3-273

757 (100)

38.4

3-142

-0.55

0.37

 7-12

4597 (78)

35.5

2-218

597 (79)

35.5

3-124

1.83

0.58

 13-18

3958 (67)

32.5

1-256

516 (68)

35.5

2-177

1.96

0.067

 19-24

3648 (62)

35.5

1-251

477 (63)

35.5

2-191

2.13

0.051

 25-30

3273 (55)

35.5

1-253

446 (59)

35.5

2-160

2.20

0.033

 31-36

2965 (50)

35.5

1-266

427 (56)

35.5

1-181

-0.89

0.028

Children, months

        

 0-6

7259 (100)

31.2

2-182

1233 (100)

28.3

3-112

-5.35

< 0.0001

 7-12

6403 (88)

29.6

2-195

1033 (84)

29.6

1-127

-3.94

0.0021

 13-18

6029 (83)

29.6

1-222

969 (79)

29.6

1-104

-4.04

0.099

 19-24

5863 (801)

35

1-222

960 (78)

31.5

2-149

-2.49

0.0002

 25-30

5685 (78)

35.5

1-163

929 (75)

32.9

2-160

-3.85

0.0030

 31-36

5511 (76)

35.5

1-305

904 (73)

35.5

2-210

-2.87

0.062

  1. ADHD attention deficit hyperactivity disorder, ASD autism spectrum disorder, mg milligram
  2. #Wilcoxon rank sum test used for group comparisons of doses
  3. A negative Z value and a p value below 0.05 indicate that individuals with ADHD and coexisting ASD are prescribed statistically significantly lower doses as compared to individuals without coexisting ASD
  4. Age categories based on age at first ADHD diagnosis (adults, age ≥ 18 years, adolescents, age 13-17 years, children, age ≤ 12 years)
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Journal of Neurodevelopmental Disorders

ISSN: 1866-1955

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