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Table 4 Attention-deficit/hyperactivity disorder (ADHD) medication mean doses (mg/day) in 6 months intervals, comparing individuals with ADHD with coexisting autism spectrum disorder (ASD) versus ADHD without coexisting ASD, and stratified analyses by sex, age category (adults/adolescents/children), substance use disorder (SUD), and intellectual disability (ID)

From: Medications for attention-deficit/hyperactivity disorder in individuals with or without coexisting autism spectrum disorder: analysis of data from the Swedish prescribed drug register

  ADHD without coexisting ASD ADHD with coexisting ASD   
  Number of subjects (%) Median Range doses (mg) Number of subjects Median Range doses (mg) Z value p value
All, months         
 0-6 25508 (100) 39.9 2-570 3467 (100) 35.7 2-437 -8.97 < 0.0001
 7-12 20661 (81) 35.5 1-799 2759 (80) 35.5 1-368 -6.32 < 0.0001
 13-18 18420 (72) 35.5 1-1065 2505 (72) 35.5 1-762 -4.56 < 0.0001
 19-24 17471 (68) 39.4 0.01-1058 2373 (68) 35.5 2-669 -4.46 < 0.0001
 25-30 16393 (64) 39.4 1-943 2269 (65) 35.5 1-674 -4.70 < 0.0001
 31-36 15508 (61) 41.4 1-879 2171 (63) 38.4 1-762 -3.55 0.0004
Adults, months         
 0-6 12327 (100) 50.3 2-570 1477 (100) 42.9 2-437 -5.35 < 0.0001
 7-12 9661 (78) 52.6 1-799 1129 (76) 44.4 2-368 -3.94 < 0.0001
 13-18 8433 (68) 52.6 2-1065 1020 (69) 44.4 1-762 -4.04 < 0.0001
 19-24 7960 (65) 53.2 0.01-1058 936 (63) 47.3 2-669 -2.49 0.0047
 25-30 7435 (60) 53.2 1-943 894 (61) 46.4 1-674 -3.85 < 0.0001
 31-36 7032 (57) 53.2 1-879 840 (57) 53.2 1-762 -2.87 0.0016
Adolescents, months         
 0-6 5922 (100) 38.4 3-273 757 (100) 38.4 3-142 -0.55 0.37
 7-12 4597 (78) 35.5 2-218 597 (79) 35.5 3-124 1.83 0.58
 13-18 3958 (67) 32.5 1-256 516 (68) 35.5 2-177 1.96 0.067
 19-24 3648 (62) 35.5 1-251 477 (63) 35.5 2-191 2.13 0.051
 25-30 3273 (55) 35.5 1-253 446 (59) 35.5 2-160 2.20 0.033
 31-36 2965 (50) 35.5 1-266 427 (56) 35.5 1-181 -0.89 0.028
Children, months         
 0-6 7259 (100) 31.2 2-182 1233 (100) 28.3 3-112 -5.35 < 0.0001
 7-12 6403 (88) 29.6 2-195 1033 (84) 29.6 1-127 -3.94 0.0021
 13-18 6029 (83) 29.6 1-222 969 (79) 29.6 1-104 -4.04 0.099
 19-24 5863 (801) 35 1-222 960 (78) 31.5 2-149 -2.49 0.0002
 25-30 5685 (78) 35.5 1-163 929 (75) 32.9 2-160 -3.85 0.0030
 31-36 5511 (76) 35.5 1-305 904 (73) 35.5 2-210 -2.87 0.062
  1. ADHD attention deficit hyperactivity disorder, ASD autism spectrum disorder, mg milligram
  2. #Wilcoxon rank sum test used for group comparisons of doses
  3. A negative Z value and a p value below 0.05 indicate that individuals with ADHD and coexisting ASD are prescribed statistically significantly lower doses as compared to individuals without coexisting ASD
  4. Age categories based on age at first ADHD diagnosis (adults, age ≥ 18 years, adolescents, age 13-17 years, children, age ≤ 12 years)
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Journal of Neurodevelopmental Disorders

ISSN: 1866-1955

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