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Table 1 Litters are rarely used as the statistical unit in NDD publications

From: Controlling litter effects to enhance rigor and reproducibility with rodent models of neurodevelopmental disorders

Category Search criteria Number of litters indicated Litter treated as statistical unit
Genetic (including molecular studies of brain development) (SCN2A AND Autism) OR (CHD8 AND Autism) OR (UBE3A AND Angelman) 2/45 (4%) 0/45 (0%)
neocortex AND development AND regulation 3/29 (10%) 1/29 (3%)
(embryonic knockout OR electroporation) AND brain development 4/25 (16%) 1/25 (4%)
Genetic total   9/99 (9%) 2/99 (2%)
Environment maternal immune activation AND autism 23/33 (67%) 6/33 (18%)
autism AND air pollution 8/9 (89%) 3/9 (33%)
BPA AND brain development 8/9 (89%) 4/9 (44%)
autism AND VPA 30/66 (45%) 10/66 (15%)
Environment total   69/117 (59%) 23/117 (20%)