Table 2 Model estimates of physiological variables change with a diagnosis by time interaction

 Intercept

5.82

0.89

99.61

6.57

< 0.001

(4.06, 7.58)

 Diagnosis

0.02

0.18

139.96

0.14

0.89

(− 0.32, 0.38)

 Time

0.37

0.07

394.14

5.54

< 0.001

(0.24, 0.51)

 Time²

− 0.08

0.02

394.09

− 4.89

< 0.001

(− 0.11, − 0.05)

 Age

0.04

0.08

98.95

0.56

0.57

(− 0.11, 0.20)

 Diagnosis*time

− 0.08

0.10

394.09

− 0.87

0.39

(− 0.27, 0.10)

 Diagnosis*time²

0.01

0.02

394.06

0.29

0.77

(− 0.04, 0.05)

 Intercept

70.06

11.01

90.34

6.36

< 0.001

(48.19, 91.93)

 Diagnosis

1.72

2.08

104.69

0.83

0.41

(− 2.41, 5.85)

 Time

0.34

0.54

340.01

0.64

0.52

(− 0.71, 1.40)

 Time²

− 0.10

0.13

339.44

− 0.82

0.41

(− 0.36, 0.15)

 Age

1.66

0.96

90.12

1.73

0.09

(− 0.25, 3.57)

 Diagnosis*time

0.18

0.77

339.72

0.23

0.81

(− 1.34, 1.70)

 Diagnosis*time²

− 0.10

0.18

339.31

− 0.55

0.58

(− 0.46, 0.26)