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Fig. 1 | Journal of Neurodevelopmental Disorders

Fig. 1

From: mTOR inhibitor improves autistic-like behaviors related to Tsc2 haploinsufficiency but not following developmental status epilepticus

Fig. 1

Induction of DSE and effects of Tsc2+/- and DSE on physical and behavioral development. a, b Pilocarpine injection induced signs of status epilepticus. Genotype of the pup had no influence on the time of the first occurrence of specific signs, and on seizure severity estimated using a modified Racine scale (n = 6 for wt, n = 6 for Tsc2+/-). c Tsc2+/- mutation did not affect body weight between P11 and P90 (n = 40 for wt, n = 30 for Tsc2+/-, DSE and saline pooled together). d Pilocarpine-induced DSE at P12 led to persistent growth retardation, which was detectable up to P40, but compensated in the adulthood (n = 33 for saline, n = 37 for DSE, Tsc2+/- and wt pooled together). e, f Pilocarpine-induced DSE led to reduction of social play and ultrasonic calling during interaction with an age- and treatment-matched conspecific at P19 (n = 8 pairs for saline, n = 9 pairs for pilocarpine, Tsc2+/- and wt pooled together). g Examples of ultrasonic calls emitted during social interaction at P19. Data are shown as means ± SEM. Three-way ANOVA with repeated measures and simple effects (a-d); t-test (e, f). *p < 0.05; **p < 0.01; ***p < 0.001

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