Fig. 4

EEG recordings and epileptiform activity. a Number of wet dog shakes in Tsc2+/- and in DSE rats. In three-way ANOVA, there was a significant increase in WDS in Tsc2+/- rats and also generalized gradual decrease across sessions. In two-way ANOVA for data averaged across all sessions, the increase was significant for both Tsc2+/- and DSE. b Incidence of WDS also decreased during the course of a session. Placement of epidural electrodes is indicated in (c), and typical examples of epileptiform patterns are shown in d and e. Data are shown as means ± SEM (n = 5 for wt naïve, n = 3 for Tsc2+/- naïve, n = 4 for wt DSE, n = 6 for Tsc2+/- DSE), significances are indicated by asterisks according to three-way ANOVA with repeated measures (in green) and two-way ANOVA (in black) and Bonferroni post hoc test. NS p > 0.05; * p < 0.05; ** p < 0.01; *** p < 0.001