TY - JOUR AU - Rahn, Rachel M. AU - Weichselbaum, Claire T. AU - Gutmann, David H. AU - Dougherty, Joseph D. AU - Maloney, Susan E. PY - 2021 DA - 2021/03/20 TI - Shared developmental gait disruptions across two mouse models of neurodevelopmental disorders JO - Journal of Neurodevelopmental Disorders SP - 10 VL - 13 IS - 1 AB - Motor deficits such as abnormal gait are an underappreciated yet characteristic phenotype of many neurodevelopmental disorders (NDDs), including Williams Syndrome (WS) and Neurofibromatosis Type 1 (NF1). Compared to cognitive phenotypes, gait phenotypes are readily and comparably assessed in both humans and model organisms and are controlled by well-defined CNS circuits. Discovery of a common gait phenotype between NDDs might suggest shared cellular and molecular deficits and highlight simple outcome variables to potentially quantify longitudinal treatment efficacy in NDDs. SN - 1866-1955 UR - https://doi.org/10.1186/s11689-021-09359-0 DO - 10.1186/s11689-021-09359-0 ID - Rahn2021 ER -