Shared developmental gait disruptions across two mouse models of neurodevelopmental disorders

Table 1 Summary of significant findings for juvenile mice and adult mice across both Nf1 and CD models

For each gait parameter, main effects of age (A) and genotype (G) are indicated where significant after FDR correction. Genotype effects shared across models are in bold. Age by genotype interactions were also explored but none survived correction. Arrows indicate the direction of the genotype effect regarding Het compared to WT (down arrows indicate lower score for Het compared to WT; up arrows indicate higher score for Het compared to WT). N = 24 Het CD mice and 44 WT CD mice; N = 30 Het Nf1^+/R681X mice and 40 WT Nf1^+/R681X mice

ISSN: 1866-1955