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Table 2 Summary of proband to family univariate analysis

From: Modeling familial predictors of proband outcomes in neurogenetic disorders: initial application in XYY syndrome

Proband feature

Correlation coefficient (r)

Offset [d];

p value

Slope

m, (s.d.)

p value of slope from m = 0

p value of slope from m = 1

Adjusted R2

FSIQ

r = 0.63

20.15 [ 1.34]

p < 2E−16*

0.94 (0.15)

p = 1.24E−07*

p = 0.684

R2 = 0.39

Vocabulary

r = 0.57

3.78 [ 1.26]

p = 2.05E−13*

0.91 (0.2)

p = 3.98E−05*

p = 0.662

R2 = 0.31

Matrix reasoning

r = 0.22

2.59 [ 0.86]

p = 1.77E−08*

0.35 (0.2)

p = 0.091

p = 0.003*

R2 = 0.03

SRS-2 Total

r = 0.065

17.04 [1.7]

p = 1.03E−13*

0.17 (0.34)

p = 0.629

p = 0.001*

R2 = − 0.01

SRS-2 Awareness

r = 0.26

13.83 [1.38]

p = 3.67E−11*

0.6 (0.29)

p = 0.045

p = 1.17E−06*

R2 = 0.05

SRS-2 Cognition

r = 0.088

17.29 [1.73]

p = 1.53E−14*

0.19 (0.28)

p = 0.51

p = 0.005

R2 = − 0.01

SRS-2 Communication

r = 0.039

17.185 [1.72]

p = 1.68E−13*

0.09 (0.33)

p = 0.774

p = 0.001*

R2 = − 0.02

SRS-2 Motivation

r = 0.15

8.49 [0.85]

p = 1.52E−06*

0.24 (0.21)

p = 0.26

p = 2.60E−07*

R2 = 0.01

SRS-2 RIRB

r = 0.056

16.85 [1.69]

p = 1.34E−12*

0.17 (0.41)

p = 0.678

p = 0.045

R2 = − 0.01

SRS-2 DSM-5 SCI

r = 0.085

16.45 [1.65]

p = 1.02E−13*

0.2 (0.31)

p = 0.524

p = 2.75E−04*

R2 = − 0.01

ADHD inattentive

r = 0.078

24.25 [2.43]

p < 2E−16*

0.09 (0.15)

p = 0.57

p = 2.17E−07*

R2 = − 0.01

ADHD hyperactive-impulsive

r = 0.22

21.85 [2.19]

p = 9.42E−15*

0.45 (0.28)

p = 0.106

p = 0.049

R2 = 0.03

  1. The [d] is Cohen’s d effect size. The slope (m) is standardized residual indicating the effect size shift in proband score associated with a 1 standard deviation shift of family score. m = 0 (comparison to horizontal line). m = 1 (comparison to identity line). p value of slope from 0 also applies to null hypothesis test for Pearson correlation coefficient. (*) indicates survived multiple hypotheses testing Bonferroni correction. The relationship between proband and relative scores for FSIQ and vocab scores were not modulated by proband age (p > 0.5). FSIQ Full-Scale Intelligence Quotient, SRS-2 Social Responsiveness Scale Second Edition, SRS-2 Awareness SRS-2 Social Awareness, SRS-2 Cognition SRS-2 Social Cognition, SRS-2 Communication SRS-2 Social Communication, SRS-2 Motivation SRS-2 Social Motivation, SRS-2 RIRB SRS-2 Restricted Interests and Repetitive Behaviors, SRS-2 DSM-5 SCI SRS-2 DSM-5 Social Communication and Interaction