Electroretinography and contrast sensitivity, complementary translational biomarkers of sensory deficits in the visual system of individuals with fragile X syndrome

Table 3 Summary characteristics of subjects participating in the study and in the retinal assessment using the RETeval® device

Study participant information¹	FXS	Control
Age^a	28.10 (6.53) [25.04-31.16]	28.80 (6.83) [25.60-32.00]
Male gender^b	20 (100%)	20 (100%)
Ethnicity^c	20 (100%) Caucasian	18 (90%)^d Caucasian
Short Sensory Profile (SSP)^e
Subcore 1: Tactile sensitivity	26.05 (4.84) - Probable difference	-
Subcore 2: Taste/smell senstivity	18.15 (1.90) - Typical performance	-
Subcore 3: Movement sensitivity	9.95 (4.27) - Definite difference	-
Subcore 4: Under-responsive/seeks sensation	28.2 (4.85) - Typical performance	-
Subcore 5: Auditory filtering	17.45 (4.16) - Definite difference	-
Subcore 6: Low energy/weak	18.65 (5.35) - Definite difference	-
Subcore 7: Visual/auditory sensitivity	16.2 (6.07) - Probable difference	-
Total Score	137.2 (19.52) - Definite difference	-
Participant information for Retinal assessments¹	FXS	Control
Age^a	28.12 (6.60) [24.72-31.51]	28.79 (7.02) [25.41-32.17]
n (eyes) LA-ERG single flash^f	26	38
n (eyes) LA-ERG flickers stimulation^f	30	38
Iris/Pupil Ratio^a	1.38 (0.12) [1.35-1.43]	1.33 (0.11) [1.30-1.37]
Electrodes vertical position^g
0 mm	0%	0%
1 mm	6.25%	10.52%
2 mm	18.75%	55.26%
3 mm	46.875%	26.31%
4 mm	28.125%	7.89%

¹Characteristics are broken out into FXS and healthy control cohorts
^aData reported as mean (SD) [95% confidence level]
^bData are reported as n (%)
^cData are reported as n (%)
^dOther two subjects were of Indian and African background
^eAssessment scores (subscores and total) for Short Sensory Profile are reported here as the mean (SD) along with each corresponding Dunn Classification [49]
^fNumber of eyes
^gData are reported as percentage (%)

ISSN: 1866-1955