Table 1 Summary of response of 86 individuals with CDD to anti-seizure medications
From: Current neurologic treatment and emerging therapies in CDKL5 deficiency disorder
Medication | # individuals | # individuals with known response | 2-week response (n, (% of those prescribed the medication with known response)) | 3-month response (n, (% of those prescribed the medication with known response)) | Worsening seizures (n, (% of those prescribed the medication with known response)) | No change (n, (% of those prescribed the medication with known response)) |
|---|---|---|---|---|---|---|
Levetiracetam | 75 | 56 (75%) | 8 (14%) | 3 (5%) | 5 (9%) | 43 (77%) |
Topiramate | 57 | 38 (67%) | 10 (26%) | 5 (13%) | 2 (5%) | 26 (68%) |
Phenobarbital | 53 | 35 (66%) | 13 (37%) | 3 (9%) | 1 (3%) | 21 (60%) |
Clobazam | 52 | 25 (48%) | 12 (48%) | 9 (36%) | 4 (16%) | 10 (40%) |
Vigabatrin | 41 | 27 (66%) | 15 (56%) | 9 (33%) | 2 (7%) | 9 (33%) |
Valproic acid | 40 | 25 (63%) | 9 (36%) | 7 (28%) | 0 | 16 (64%) |
Oxcarbazepine | 31 | 20 (65%) | 5 (25%) | 2 (10%) | 3 (15%) | 12 (60% |
ACTH | 30 | 19 (19%) | 8 (42%) | 0 | 1 (5%) | 10 (53% |
Clonazepam | 30 | 11 (37%) | 0 | 0 | 2 (18%) | 9 (82%) |
Prednisolone/prednisone | 28 | 21 (75%) | 7 (33%) | 0 | 1 (5%) | 13 (62%) |
Rufinamide | 28 | 15 (54%) | 7 (47%) | 4 (27%) | 3 (20%) | 6 (40%) |
Lamotrigine | 26 | 15 (58%) | 6 (40%) | 2 (13%) | 1 (7%) | 8 (53%) |
Zonisamide | 22 | 13 (59%) | 0 | 0 | 1 (8%) | 12 (92%) |
Cannabidiol (Epidiolex) | 19 | 14 (74%) | 4 (29%) | 3 (21%) | 4 (29%) | 6 (43%) |
Lacosamide | 12 | 9 (75%) | 0 | 0 | 2 (22%) | 7 (78%) |
Felbamate | 11 | 5 (45%) | 1 (20%) | 1 (20%) | 0 | 4 (80%) |
Carbamazepine | 10 | 6 (60%) | 0 | 0 | 0 | 6 (100%) |
Phenytoin | 10 | 8 (80%) | 1 (13%) | 1 (13%) | 2 (25%) | 5 (63%) |
Clorazepate | 7 | 4 (57%) | 0 | 0 | 1 (25%) | 3 (75%) |
Gabapentin | 5 | 4 (80%) | 0 | 0 | 0 | 4 (100%) |
Perampanel | 5 | 4 (80%) | 0 | 0 | 0 | 4 (100%) |
Ethosuximide | 4 | 1 (25%) | 0 | 0 | 0 | 1 (100%) |
Diazepam | 3 | 1 (33%) | 0 | 0 | 0 | 1 (100%) |
Lorazepam | 3 | 2 (67%) | 1 (50%) | 1 (50%) | 2 (100%) | 0 |
Nitrazepam | 3 | 1 (33%) | 0 | 0 | 0 | 1 (100%) |
Pregabalin | 3 | 1 (33%) | 0 | 0 | 0 | 1 (100%) |
Methsuximide | 2 | 1 (50%) | 0 | 0 | 0 | 1 (100%) |
Midazolam | 2 | 2 (100%) | 0 | 0 | 0 | 2 (100%) |
Acetazolamide | 1 | 0 | 0 | 0 | 0 | 0 |
Brivaracetam | 1 | 1 (100%) | 1 (100%) | 1 (100%) | 0 | 0 |
Fosphenytoin | 1 | 1 (100%) | 0 | 0 | 0 | 1 (100%) |
Stiripentol | 1 | 0 | 0 | 0 | 0 | 0 |
Tiagabine | 1 | 1 (100%) | 0 | 0 | 0 | 1 (100%) |