Fig. 1

Mean parental QATs according to presence of ASD-associated pathogenic variants in offspring. QAT distributions for either mothers, fathers, or averaged parental SRS-2 scores have a slightly higher mean and wider range (encompassing higher scores) in families for which an ASD-affected child does not have known ASD-associated de novo variants, versus families in which the ASD-affected child has a known de novo variant. For parents of a child with known de novo variant, correlation of parental SRS-2 scores are as follows: r=0.26 (0.15, 0.36), p<.001; for parents of a child with unknown variants: r=0.31 (0.27, 0.34), p<.001)