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Fig. 1 | Journal of Neurodevelopmental Disorders

Fig. 1

From: Increased 2-arachidonoyl-sn-glycerol levels normalize cortical responses to sound and improve behaviors in Fmr1 KO mice

Fig. 1

Effects of JZL-184 treatment on mouse cortical lipidomic profile. Mouse brain levels of 2-arachidonoyl-sn-glycerol (2-AG, A), docosahexaenoylglycerol (DHAG, B), 2-oleoylglycerol (2-OG, C), 2-linoleoyl glycerol (2-LG, D), anandamide (AEA, E), oleoylethanolamide (OEA, F), and docosahexaenoyl ethanolamide (DHEA, G) 4 h post-treatment in Fmr1 KO and WT mice treated with 4, 8, or 16 mg/kg JZL-184 or vehicle. Values represent means per group and error bars indicate the standard error of the mean (SEM). Statistical analysis was performed using the two-way ANOVA for all comparisons. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Vehicle WT, N = 8–9; 4 mg/kg JZL-184 WT, N = 6–7; 8 mg/kg JZL-184 WT, N = 7; 16 mg/kg JZL-184 WT, N = 4–5; vehicle Fmr1 KO, N = 9–10; 4 mg/kg JZL-184 Fmr1 KO, N = 9; 8 mg/kg JZL-184 Fmr1 KO, N = 9; 16 mg/kg JZL-184 Fmr1 KO, N = 5. Excluded: AEA, 4 mg/kg JZL-184 WT, N = 1; vehicle Fmr1 KO, N = 1. OEA, 16 mg/kg JZL-184 WT, N = 1. DHAG, vehicle WT, N = 1

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