Fig. 3

Phenotypes and effective compounds in the models ex21|PRO and ex4-9|ANK. The phenotypes of the respective models are summarized according to the categories and interpretations, which were assigned to the performed experiments. On the y-axis the abnormality score (1 = normal; 2 = abnormal) is plotted per interpretation on the x-axis. Concentric circles are added around the circular barplot to illustrate the influence of a subset of treatment strategies on the phenotypes. Bold black lines indicate a full rescue of the observed deficits, while thinner grey lines indicate a partial normalization of the respective phenotype. Importantly, only beneficial effects were included in this visualization. The abbreviations used in this illustration are summarized in Table 1