Table 3 Results of the rare variant analyses
Phenotype | ASD | Childhood autism | Asperger’s syndrome | ADHD | Schizophrenia | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Number of variants | P value | Rho | Number of variants | P value | Rho | Number of variants | P value | Rho | Number of variants | P value | Rho | Number of variants | P value | Rho |
NOP9 | 61 | 0.059 | 0 | 46 | 0.103 | 0 | 49 | 0.108 | 0.5 | 57 | 0.242 | 0 | 47 | 0.111 | 0.4 |
KMT2D | 454 | 0.227 | 0 | 361 | 0.545 | 0 | 361 | 0.319 | 1 | 435 | 0.533 | 1 | 337 | 0.126 | 0.7 |
RORB | 14 | 0.243 | 1 | 11 | 0.033 | 1 | 12 | 0.894 | 1 | 14 | 0.300 | 1 | 11 | 0.397 | 1 |
ABCC13 | 1 | 0.138 | NA | 1 | 0.180 | NA | 1 | 0.584 | NA | 1 | 0.383 | NA | 1 | 0.079 | NA |
NDST4 | 45 | 0.011 | 0.4 | 42 | 0.270 | 1 | 43 | 0.117 | 0.4 | 48 | 0.215 | 1 | 44 | 0.142 | 1 |
FAT3 | 361 | 0.361 | 1 | 289 | 0.549 | 1 | 291 | 0.420 | 1 | 337 | 0.144 | 0.6 | 278 | 0.726 | 0 |
CMIP | 22 | 0.402 | 1 | 18 | 1.000 | 1 | 18 | 0.637 | 0 | 23 | 1.000 | 0 | 17 | 0.715 | 0 |
PALB2 | 83 | 0.551 | 0 | 64 | 0.592 | 0 | 67 | 0.827 | 1 | 75 | 0.747 | 1 | 65 | 0.633 | 0 |
SCN9A | 130 | 0.093 | 0 | 103 | 0.578 | 0 | 109 | 0.396 | 0 | 126 | 0.153 | 0 | 102 | 0.308 | 1 |
MUC6 | 31 | 0.857 | 1 | 27 | 0.816 | 0 | 28 | 1.000 | 1 | 32 | 0.752 | 1 | 28 | 0.815 | 1 |
NFXL1 | 26 | 0.519 | 1 | 13 | 0.695 | 0 | 15 | 0.235 | 1 | 17 | 0.849 | 1 | 13 | 0.559 | 0 |
OXR1 | 41 | 0.572 | 0.7 | 34 | 0.876 | 1 | 34 | 0.779 | 1 | 41 | 0.365 | 0 | 34 | 0.497 | 1 |
ATP2C2 | 161 | 0.895 | 1 | 122 | 0.460 | 0 | 131 | 0.317 | 1 | 159 | 0.359 | 1 | 118 | 0.650 | 1 |
SETBP1 | 106 | 0.777 | 1 | 88 | 0.790 | 1 | 91 | 0.365 | 1 | 105 | 0.322 | 1 | 85 | 0.018 | 1 |
CNTNAP2 | 0 | NA | NA | 0 | NA | NA | 0 | NA | NA | 0 | NA | NA | 0 | NA | NA |