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Table 2 Regions showing main effect of group in the whole brain RFX ANOVA analysis (F ≥4.21; p<.05, corrected for multiple comparisons): summary of RFX-GLM contrasts, outputs, and statistics

From: Parahippocampal deactivation and hyperactivation of central executive, saliency and social cognition networks in autism spectrum disorder

Region

BA

Peak MNI coordinates

   

No cue

Non-social cue

Social cue

X

Y

Z

No of voxels

F

p

t

p

t

p

t

p

ASD > TD

 RH middle temporal/occipital gyrus

37

53

− 55

− 2

1190

12.12

.002

4.006

< .001

4.969

< .001

3.943

.001

 RH temporal pole

38

41

20

− 22

664

11.51

.002

3.242

< .001

4.812

< .001

3.668

< .001

 RH primary somatosensory cortex/somatosensory association cortex/supramarginal gyrus

1/7/40

32

− 37

57

2726

16.02

< .001

5.114

< .001

6.073

< .001

5.820

.001

 RH primary somatosensory cortex

1/4

19

− 31

57

710

10.13

.004

4.373

< .001

4.421

< .001

3.943

.001

 Primary motor cortex

 L/RH supplementary motor area

6

− 2

− 28

54

2285

15.15

< .001

5.162

< .001

5.721

< .001

5.467

< .001

 L/RH ventromedial prefrontal cortex/pregenual anterior cingulate cortex

32

− 6

50

− 8

4439

19.04

< .001

4.575

< .001

5.611

< .001

3.690

< .001

 Orbitofrontal cortex

10/11

 LH middle frontal gyrus

10

− 33

51

− 1

1979

13.69

.001

3.509

.002

3.391

.003

3.692

.001

 LH middle temporal gyrus

21/22

− 60

− 19

5

10826

22.10

< .001

5.405

< .001

7.688

< .001

4.703

< .001

 LH middle frontal gyrus

8/9

− 30

24

42

1347

14.18

< .001

4.040

< .001

4.389

< .001

4.040

.001

 LH inferior parietal lobule

40

− 38

− 49

53

805

12.02

.002

5.114

< .001

6.073

< .001

5.820

< .001

 Claustrum

 

− 37

− 2

− 18

618

10.42

.003

2.152

< .001

4.530

< .001

3.367

< .001

 LH inferior frontal gyrus/ventrolateral prefrontal cortex

45/46/47

− 50

− 2

− 18

3552

15.38

< .001

4.512

< .001

5.440

< .001

3.851

.001

 LH temporal parietal junction

22/40

− 60

− 27

21

1937

19.70

< .001

5.108

< .001

4.747

< .001

4.928

< .001

TD > ASD

 RH parahippocampal gyrus

19

26

− 49

− 7

586

11.18

.002

− 4.008

.001

− 4.318

.001

− 4.198

.001

 LH parahippocampal gyrus

18/19

− 16

− 72

1

1810

15.41

< .001

− 8.547

< .001

− 9.091

< .001

− 8.479

< .001

  1. Note. Brain regions showing significant whole-brain RFX-ANOVA group effect (p < .05, corrected for multiple comparisons) and ROI-based GLM-RFX contrasts for group differences between responses to Social, Non-Social and No Cue conditions. Positive t-tests indicate higher β values for the ASD group than for TD. Negative t-tests indicate higher β values for the TD group than for ASD. X, Y and Z represent MNI coordinates. Significant comparisons are marked in bold. BA, Brodmann area; ASD, autism spectrum disorder group; TD, typical neurodevelopment group, RH, right hemisphere, LH, left hemisphere
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Journal of Neurodevelopmental Disorders

ISSN: 1866-1955

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