Table 5 Study information of scoping review TAND s according to study type

Sample characteristics

Species:

 • Mice (n = 26; 87%)

 • Rats (n = 4; 13%)

Sex:

 • Male (n = 25; 53%)

 • Female (n = 14; 30%)

 • Multiple case series (n = 8; 17%)

Age distribution^a:

 • Infant 0–3 years (n = 9; 19%)

 • Child 4–10 years (n = 18; 38%)

 • Adolescent 11–19 years (n = 16; 34%)

 • Adult 20–60 years (n = 17; 36%)

 • Older adult 60+ years (n = 1; 2%)

Sex ratio reported:

 • 130 (85%)

Age distribution^a:

 • Infant 0–3 years (n = 90; 59%)

 • Child 4–10 years (n = 97; 63%)

 • Adolescent 11–19 years (n = 96; 63%)

 • Adult 20–60 years (n = 70; 46%)

 • Older adult 60+ years (n = 24; 16%)

Sample size:

 • ≤ 50 (n = 88; 58%)

 • 51–100 (n = 28; 18%)

 • 101–200 (n = 17; 11%)

 • 201–500 (n = 13; 9%)

 • 501–1000 (n = 4; 3%)

 • ≥ 1001 (n = 3; 2%)

Mixed caregiver patient cohort:

 • 7 (5%)

Clinical information

Genetic information:

 • TSC1 (n = 8; 27%)

 • TSC2 (n = 22; 73%)

Epilepsy information provided:

 • 39 (83%)

IQ information provided:

 • 31 (66%)

Genetic confirmation provided:

 • 11 (23%)

Epilepsy information provided:

 • All (n = 110; 72%)

 • Some (n = 14; 9%)

 • None (n = 29; 19%)

IQ information provided:

 • All (n = 93; 61%)

 • Some (n = 21; 14%)

 • None (n = 39; 26%)

Genetic confirmation provided:

 • All (n = 26; 17%)

 • Some (n = 34; 22%)

 • None (n = 93; 61%)

World Bank Classification

HIC (n = 30; 100%)

LMIC (n = 0; 0%)

Multisite HIC and LMIC N/A

HIC (n = 33; 70%)

LMIC (n = 14; 30%)

Multisite HIC and LMIC N/A

HIC (n = 138; 90%)

LMIC (n = 10; 7%)

Multisite HIC and LMIC (n = 5; 3%)

Sample identification^a

N/A

N/A

Population (n = 9; 6%)

Clinical (n = 108; 71%)

Community (n = 47; 31%)

Quality rating

Relatively high (n = 8; 27%)

High (n = 22; 73%)

Relatively high (n = 16; 34%)

High (n = 31; 66%)

Low (n = 4; 3%)

Adequate (n = 26; 17%)

Relatively high (n = 84; 55%)

High (n = 39; 25%)