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Fig. 5 | Journal of Neurodevelopmental Disorders

Fig. 5

From: Computational analysis of cortical neuronal excitotoxicity in a large animal model of neonatal brain injury

Fig. 5

Multi-parametric global sensitivity analysis (MPGSA) of the Ca2+/CaM-Src model. a All simulation runs (dotted grey lines) over time course; mean model simulation response (red), and the 90% region (blue) for all simulation runs for nuclear Ca2+ influx (top) and Bax expression (bottom). b Cumulative distribution function plots for MPGSA with classifier max(nuclear Ca2+) > 10 μM (left) and max(Bax expression) > 1 μM (right), showing accepted (blue) and rejected (red) sample simulation values. Asterisks represents P < 0.0001 for Kolmogorov-Smirnov test to identify difference between accepted and rejected CDFs. [Statistics: (max(Bax) > 1 μM: CaMKIV: K-S: 0.0247; P = 0.9991; CREB: K-S: 0.4137; P < 0.0001; NMDAR: P = 0.9992, K-S: 0.0246; hyperstim: P < 0.0001; K-S: 0.7736; stim: P > 0.05; K-S: 0.0193; max(nuclear Ca2+ > 10 μM): CaMKIV: P > 0.05, K-S: 0.0139; CREB: P > 0.05, K-S = 0.0136; NMDAR: P > 0.05, K-S = 0.0153; hyperstim: P < 0.0001, K-S = 1; stim: P > 0.05, K-S = 0.0104]

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