Molecule | Experimental data | Simulation data | Trend match/mismatch | Accuracy (Effect of PP2) | ||
---|---|---|---|---|---|---|
Hx to Hx + PP2 (% change w.r.t Hx) | Hx to Hx + PP2 (% change w.r.t Hx) | |||||
change | trend | change | trend | |||
Validation analyses | ||||||
 Nuclear Ca2+ | -28.07 | ▼ | -44.85 | ▼ | Match | 40.22%; overestimate |
 Activated Ca2+/CaM | -63.22 | ▼ | -43.63 | ▼ | Match | 69.01%; underestimate |
 Activated CaMKIV | -59.10 | ▼ | -65.27 | ▼ | Match | 89.56%; overestimate |
 Activated CREB | -36.84 | ▼ | -91.20 | ▼ | Match | 47.56%; overestimate |
Predictive analysis (test validation) | ||||||
 Activated CaMKK(2) | -42.81 | ▼ | -42.38 | ▼ | Match | 99.0%; underestimate |