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Table 4 Parameter estimates from age-based mixed models (Pm group by FXTAS status)

From: Neuropsychological changes in FMR1 premutation carriers and onset of fragile X-associated tremor/ataxia syndrome

  Estimate (SE) t-value P
Visual episodic memory (PAL errors)
 Intercept 7.06 (3.07) 2.30 .025
 Age .572 (.163) 3.51 .001
 FXTAS intercept 1.56 (5.38) 0.29 .773
 FXTAS slope − .035 (.239) − 0.15 .883
Verbal episodic memory (WMS LM2 score)
 Intercept 26.60 (1.86) 14.3 .001
 Age − .004 (.095) − 0.04 .970
 FXTAS intercept − 4.07 (3.13) − 1.31 .193
 FXTAS slope .131 (.136) 0.97 .336
Auditory working memory (WMS LNS score)
 Intercept 12.93 (.892) 14.5 .001
 Age − .084 (.041) − 2.07 .042
 FXTAS intercept − .714 (1.27) − 0.56 .575
 FXTAS slope .007 (.054) 0.13 .897
Visual working memory (SWM errors)
 Intercept 33.77 (8.15) 4.15 .001
 Age .108 (.375) 0.29 .773
 FXTAS intercept − 17.75 (12.6) − 1.41 .162
 FXTAS slope .654 (.542) 1.21 .232
Motor dexterity (Purdue Pegboard score)
 Intercept 39.56 (1.62) 24.5 .001
 Age − .245 (.073) − 3.37 .001
 FXTAS intercept − 2.53 (2.25) − 1.13 .264
 FXTAS slope .044 (.095) 0.46 .647
Inhibitory control§ (SST reaction time)
 Intercept 495.3 (47.2) 10.5 .001
 Age 5.44 (2.29) 2.37 .020
 FXTAS intercept 186.1 (75.7) 2.46 .016
 FXTAS slope − 6.56 (3.27) − 2.00 .049
Visual attention (RVP score)
 Intercept .960 (.016) 61.7 .001
 Age − .001 (.001) − 1.88 .064
 FXTAS intercept − .010 (.028) − 0.35 .724
 FXTAS slope .001 (.001) 0.05 .956
Planning (OTS score)
 Intercept 11.03 (.796) 13.8 .001
 Age − .023 (.038) − 0.61 .544
 FXTAS intercept 1.83 (1.14) 1.60 .115
 FXTAS slope − .072 (.049) − 1.46 .149
Executive control of movement (BDS-2 score)
 Intercept 23.48 (.977) 24.1 .001
 Age − .080 (.041) − 1.93 .053
 FXTAS intercept − .111 (1.33) − 0.08 .934
 FXTAS slope .033 (.054) 0.61 .541
Manual movement speed (RT)
 Intercept 185.2 (22.6) 8.18 .001
 Age 4.85 (1.17) 4.16 .001
 FXTAS intercept 95.0 (38.9) 2.44 .017
 FXTAS slope − 2.97 (1.71) − 1.74 .086
Manual reaction time (RT)
 Intercept 314.6 (13.0) 24.1 .001
 Age 1.49 (.941) 1.58 .118
 FXTAS intercept − 7.95 (28.7) − 0.28 .782
 FXTAS slope 1.86 (1.44) 1.30 .199
  1. “Intercept” = Value at age 40 for individuals without FXTAS. “Age” = change in value per year of age for individuals without FXTAS. “FXTAS intercept” = change in intercept value for individuals with FXTAS. “FXTAS slope” = change in slope value for individuals with FXTAS. “0= (=)” = parameter fixed to zero. Only Pm participants included. Nno FXTAS = 44, 26, 16 (visit 1 – visit 3); NFXTAS = 24, 20, 21 (visit 1 – visit 3). * < .05, + < .10 after Benjamini Hochberg correction for multiple comparisons