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Table 4 Parameter estimates from age-based mixed models (Pm group by FXTAS status)

From: Neuropsychological changes in FMR1 premutation carriers and onset of fragile X-associated tremor/ataxia syndrome

 

Estimate (SE)

t-value

P

Visual episodic memory (PAL errors)

 Intercept

7.06 (3.07)

2.30

.025

 Age

.572 (.163)

3.51

.001

 FXTAS intercept

1.56 (5.38)

0.29

.773

 FXTAS slope

− .035 (.239)

− 0.15

.883

Verbal episodic memory (WMS LM2 score)

 Intercept

26.60 (1.86)

14.3

.001

 Age

− .004 (.095)

− 0.04

.970

 FXTAS intercept

− 4.07 (3.13)

− 1.31

.193

 FXTAS slope

.131 (.136)

0.97

.336

Auditory working memory (WMS LNS score)

 Intercept

12.93 (.892)

14.5

.001

 Age

− .084 (.041)

− 2.07

.042

 FXTAS intercept

− .714 (1.27)

− 0.56

.575

 FXTAS slope

.007 (.054)

0.13

.897

Visual working memory (SWM errors)

 Intercept

33.77 (8.15)

4.15

.001

 Age

.108 (.375)

0.29

.773

 FXTAS intercept

− 17.75 (12.6)

− 1.41

.162

 FXTAS slope

.654 (.542)

1.21

.232

Motor dexterity (Purdue Pegboard score)

 Intercept

39.56 (1.62)

24.5

.001

 Age

− .245 (.073)

− 3.37

.001

 FXTAS intercept

− 2.53 (2.25)

− 1.13

.264

 FXTAS slope

.044 (.095)

0.46

.647

Inhibitory control§ (SST reaction time)

 Intercept

495.3 (47.2)

10.5

.001

 Age

5.44 (2.29)

2.37

.020

 FXTAS intercept

186.1 (75.7)

2.46

.016

 FXTAS slope

− 6.56 (3.27)

− 2.00

.049

Visual attention (RVP score)

 Intercept

.960 (.016)

61.7

.001

 Age

− .001 (.001)

− 1.88

.064

 FXTAS intercept

− .010 (.028)

− 0.35

.724

 FXTAS slope

.001 (.001)

0.05

.956

Planning (OTS score)

 Intercept

11.03 (.796)

13.8

.001

 Age

− .023 (.038)

− 0.61

.544

 FXTAS intercept

1.83 (1.14)

1.60

.115

 FXTAS slope

− .072 (.049)

− 1.46

.149

Executive control of movement (BDS-2 score)

 Intercept

23.48 (.977)

24.1

.001

 Age

− .080 (.041)

− 1.93

.053

 FXTAS intercept

− .111 (1.33)

− 0.08

.934

 FXTAS slope

.033 (.054)

0.61

.541

Manual movement speed (RT)

 Intercept

185.2 (22.6)

8.18

.001

 Age

4.85 (1.17)

4.16

.001

 FXTAS intercept

95.0 (38.9)

2.44

.017

 FXTAS slope

− 2.97 (1.71)

− 1.74

.086

Manual reaction time (RT)

 Intercept

314.6 (13.0)

24.1

.001

 Age

1.49 (.941)

1.58

.118

 FXTAS intercept

− 7.95 (28.7)

− 0.28

.782

 FXTAS slope

1.86 (1.44)

1.30

.199

  1. “Intercept” = Value at age 40 for individuals without FXTAS. “Age” = change in value per year of age for individuals without FXTAS. “FXTAS intercept” = change in intercept value for individuals with FXTAS. “FXTAS slope” = change in slope value for individuals with FXTAS. “0= (=)” = parameter fixed to zero. Only Pm participants included. Nno FXTAS = 44, 26, 16 (visit 1 – visit 3); NFXTAS = 24, 20, 21 (visit 1 – visit 3). * < .05, + < .10 after Benjamini Hochberg correction for multiple comparisons
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Journal of Neurodevelopmental Disorders

ISSN: 1866-1955

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