Fig. 1

RCAN1 mediates the circadian periodicity but not the photic entrainment of wheel running. Heatmap-style actograms visualizing mean wheel revolution data for two distinct cohorts of mice tested in either LD12:12 conditions for a minimum of 7 days (days 4−7 displayed) or DD conditions for a minimum of 9 days (days 4−9 displayed) for A Rcan1 WT, B Rcan1 KO, C NTG, and D RCAN1 TG groups. E Light-entrained diurnal period length of wheel running rhythms in LD12:12. There were no group differences in light-entrained period length. F Circadian (free-running) period length of wheel running rhythms in constant darkness. Young Rcan1 KO and RCAN1 TG mice have lengthened endogenous periods (tau) relative to young Rcan1 WT and NTG mice, respectively. Light-entrained N = 55 Rcan1 WT, 54 Rcan1 KO, 35 NTG, 36 RCAN1 TG mice; free-running N = 17 Rcan1 WT, 21 Rcan1 KO, 17 NTG, 18 RCAN1 TG mice. All data are mean ± S.E.M. *p < 0.05