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Fig. 2 | Journal of Neurodevelopmental Disorders

Fig. 2

From: RCAN1 knockout and overexpression recapitulate an ensemble of rest-activity and circadian disruptions characteristic of Down syndrome, Alzheimer’s disease, and normative aging

Fig. 2

RCAN1 knockout and overexpression alter active and inactive phase wheel running patterns in light-entrained young but not aged mice. A Mean total daily wheel running of light-entrained young (left) and aged (right) mice. Young Rcan1 KO and RCAN1 TG mice exhibit reduced total daily wheel running relative to young RCAN1 WT and NTG controls, respectively. Compared with young mice, aged mice showed decreased total daily wheel running. B Mean daily dark phase (ZT12-ZT24) wheel running of light-entrained young (left) and aged (right) mice. Young Rcan1 KO and RCAN1 TG mice are hypoactive during the dark phase compared with young Rcan1 WT and NTG controls, respectively. Compared with young mice, aged mice showed decreased daily wheel running during the dark phase. C Mean daily light phase (ZT0-ZT12) wheel running of light-entrained young (left) and aged (right) mice. Young Rcan1 KO mice are hyperactive during the light phase compared with both young Rcan1 WT and RCAN1 TG mice as well as with aged Rcan1 KO mice. By contrast, young RCAN1 TG mice are hypoactive compared with young NTG controls. D Mean percentage of total daily wheel running during the light phase for light-entrained young (left) and aged (right) mice. Young Rcan1 KO mice have an increased percentage of total daily activity occurring during the light phase compared with young Rcan1 WT and RCAN1 TG mice. Young N = 25 Rcan1 WT, 26 Rcan1 KO, 15 NTG, 17 RCAN1 TG mice; aged N = 7 Rcan1 WT, 10 Rcan1 KO, 7 NTG, 8 RCAN1 TG mice. All data are mean ± S.E.M. *p < 0.05; **p < 0.01; ***p < 0.001

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