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Fig. 3 | Journal of Neurodevelopmental Disorders

Fig. 3

From: RCAN1 knockout and overexpression recapitulate an ensemble of rest-activity and circadian disruptions characteristic of Down syndrome, Alzheimer’s disease, and normative aging

Fig. 3

RCAN1 knockout and overexpression similarly attenuate the light-entrained diurnal rhythmicity of wheel running in young but not aged mice. Plots of average daily wheel revolutions collapsed into hourly bins (floating points depicting mean ± S.E.M) with superimposed single-harmonic regression curve fits (mean ± 95% CI bands) for A young and B aged mice. C Mean daily MESOR estimates for wheel running rhythms of light-entrained young (left) and aged (right) mice. Young Rcan1 KO and RCAN1 TG mice have decreased MESOR estimates versus young Rcan1 WT and NTG mice, respectively. Aged Rcan1 WT and NTG mice showed reduced MESOR estimates relative to young Rcan1 WT and NTG mice, respectively. D Mean daily amplitude estimates for wheel running rhythms of light-entrained young (left) and aged (right) mice. Young Rcan1 KO and RCAN1 TG mice have reduced amplitude estimates compared with young Rcan1 WT and NTG mice, respectively. Aged Rcan1 WT and NTG mice showed decreased amplitude estimates relative to young Rcan1 WT and NTG mice, respectively. E Mean daily acrophase estimates for wheel running rhythms of light-entrained young adult (left) and aged (right) mice. There were no group differences in acrophase estimates. Young N = 25 Rcan1 WT, 26 Rcan1 KO, 15 NTG, 17 RCAN1 TG mice; aged N = 7 Rcan1 WT, 10 Rcan1 KO, 7 NTG, 8 RCAN1 TG mice. All data are mean ± S.E.M. **p < 0.01; ***p < 0.001

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