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Fig. 6 | Journal of Neurodevelopmental Disorders

Fig. 6

From: RCAN1 knockout and overexpression recapitulate an ensemble of rest-activity and circadian disruptions characteristic of Down syndrome, Alzheimer’s disease, and normative aging

Fig. 6

Photic entrainment and circadian periodicity of wheel running are unaltered in young Dp16 mice independent of Rcan1 copy number. Heatmap-style actograms visualizing mean wheel revolution data for A WT, B Dp16, and C Dp16/Rcan12N mice tested in LD12:12 conditions for 14 days (days 8–14 displayed) and immediately transferred to and tested in DD conditions for 14 days (days 1–14 displayed). D Mean wheel running period lengths for light-entrained (left) and free-running (right) young mice. No group differences in either light-entrained or free-running (endogenous) period length were detected. N = 12 WT, 17 Dp16, 13 Dp16/Rcan12N mice. All data are mean ± S.E.M.

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Journal of Neurodevelopmental Disorders

ISSN: 1866-1955

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