Fig. 7

Altered wheel running patterns in light-entrained and free-running young Dp16 mice are partially normalized by restoration of Rcan1 to two copies. A Mean total daily wheel running of light-entrained (left) and free-running (right) young mice. Light-entrained young Dp16 mice exhibited decreased total daily wheel running compared with WT and Dp16/Rcan1^2N mice. Free-running young Dp16 mice displayed reduced total daily wheel running relative to both WT and Dp16/Rcan1^2N mice, and free-running young Dp16/Rcan1^2N mice exhibited decreased total daily wheel running versus WT mice. B Mean daily active phase wheel running of light-entrained (left) and free-running (right) young mice. Light-entrained young Dp16 mice exhibited decreased active phase wheel running compared with WT and Dp16/Rcan1^2N mice. Free-running young Dp16 mice displayed reduced active phase wheel running relative to both WT and Dp16/Rcan1^2N mice, and free-running young Dp16/Rcan1^2N mice exhibited decreased active phase wheel running versus WT mice. C Mean daily inactive phase wheel running of light-entrained (left) and free-running (right) young mice. No group differences were detected for inactive phase wheel running among light-entrained mice. However, free-running young Dp16 mice displayed reduced inactive phase wheel running relative to WT mice. D Mean percentage of total daily wheel running during the inactive phase for light-entrained (left) and free-running (right) young mice. Light-entrained young Dp16 mice exhibited increased percent inactive phase wheel running compared with WT and Dp16/Rcan1^2N mice. No group differences were detected for percent inactive phase wheel running among free-running mice. N = 12 WT, 17 Dp16, 13 Dp16/Rcan1^2N mice. All data are mean ± S.E.M. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001