Fig. 8

Light-entrained diurnal and circadian wheel running rhythms are diminished in young Dp16 mice and are partially normalized by restoration of Rcan1 to two copies. Plots of average daily wheel revolutions collapsed into hourly bins (floating points depicting mean ± S.E.M) with superimposed single-harmonic regression curve fits (mean ± 95% CI bands) for A light-entrained and B free-running young mice. C Mean daily MESOR estimates for wheel running rhythms of light-entrained (left) and free-running (right) young mice. Light-entrained young Dp16 mice exhibited decreased MESOR estimates compared with WT and Dp16/Rcan1^2N mice. Free-running young Dp16 mice displayed reduced MESOR estimates relative to both WT and Dp16/Rcan1^2N mice, and free-running young Dp16/Rcan1^2N mice exhibited decreased MESOR estimates versus WT mice. D Mean daily amplitude estimates for wheel running rhythms of light-entrained (left) and free-running (right) young mice. Light-entrained young Dp16 mice exhibited decreased amplitude estimates compared to WT and Dp16/Rcan1^2N mice. Free-running young Dp16 mice displayed reduced amplitude estimates relative to both WT and Dp16/Rcan1^2N mice, and free-running young Dp16/Rcan1^2N mice exhibited decreased amplitude estimates versus WT mice. E Mean daily acrophase estimates for wheel running rhythms of light-entrained (left) and free-running (right) young mice. There were no group differences in acrophase estimates. N = 12 WT, 17 Dp16, 13 Dp16/Rcan1^2N mice. All data are mean ± S.E.M. *p < 0.05; **p < 0.01; ****p < 0.0001