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Table 2 Associations between genetic evidence of dysfunction in cerebral cortex development and sleep duration in different age groups

From: Calculating genetic risk for dysfunction in pleiotropic biological processes using whole exome sequencing data

Phenotype Variable

β†

SE

t-statistic

p-value

Preschool Age Children (n = 396)

  Sleep Duration (240–780 min)

2.32 × 10–5

1.15 × 10–5

2.01

4.47 × 10–2

  Full Scale IQ (range = 19–150)

-1.13 × 10–5

3.36 × 10–5

-0.34

7.36 × 10–1

  Age (range = 4–5 years)

-1.15 × 10–4

1.61 × 10–4

-0.71

4.76 × 10–1

  Male Sex (n = 339)

-4.34 × 10–4

2.47 × 10–3

-0.18

8.60 × 10–1

Primary School-Age Children (n = 1,467)

  Sleep Duration (240–720 min)

1.88 × 10–6

6.71 × 10–6

0.28

7.79 × 10–1

  Full Scale IQ (range = 10–165)

6.46 × 10–6

1.70 × 10–5

0.38

7.04 × 10–1

  Age (range = 6–12 years)

-4.02 × 10–5

2.02 × 10–5

-1.99

4.72 × 10–2

  Male Sex (n = 1,273)

-5.30 × 10–4

1.34 × 10–3

-0.40

6.93 × 10–1

Secondary School-Age Teenagers (n = 425)

  Sleep Duration (210–720 min)

4.71 × 10–5

1.66 × 10–5

2.85

4.65 × 10–3

  Full Scale IQ (range = 7–161)

-5.13 × 10–5

3.47 × 10–5

-1.48

1.39 × 10–1

  Age (range = 13–18 years old)

1.28 × 10–4

5.83 × 10–5

2.19

2.90 × 10–2

  Male Sex (n = 362)

-5.59 × 10–3

3.01 × 10–3

-1.86

6.40 × 10–2

  1. Shown are results from tests for a relationship between dysfunctional biological process (DBP) scores for cerebral cortex development (GO:0,021,987) and parent-reports of sleep durations in n = 2,288 individuals diagnosed with ASD. Tests were conducted within different age groups based on school age. Models adjusted for intellectual quotients, reported age at ascertainment, genetically-determined sex and reported race. Provided are ranges for quantitative measures, or the number of individuals in each category for categorical variables. †For each one unit increase in the DBP score, the β-coefficient reflects the amount each measure either decreases or increases. P-values represent the probability that there is no effect