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Table 2 Differences in SIPS-measured sleep disturbance between groups

From: Copy number variation at the 22q11.2 locus influences prevalence, severity, and psychiatric impact of sleep disturbance

Covariates

Effect of time

Effect of covariate

Effect of subject group

Group × time interaction

Cross-sectional

β

p-value

Group

β

p-value

Group

β

q-value

β

p-value

 Age + sex

-

-

-

0.198

0.004

Del

0.728

<0.001

-

-

   

-

-

-

Dup

0.741

<0.001

-

-

 Age+ sex + attention

-

-

-

0.222

0.015

Del

0.525

0.009

-

-

   

-

  

Dup

0.592

0.014

-

-

 Age+ sex + medication

-

-

Antipsychotic

0.557

0.026

Del

0.580

<0.001

-

-

   

Mood Stabilizer

0.242

0.354

Dup

0.675

<0.001

-

-

   

Stimulant

−0.027

0.932

-

-

-

-

-

   

Other

0.521

0.107

-

-

-

-

-

 Age + sex + IQ

-

-

-

−0.128

0.244

Del

0.516

0.026

-

-

      

Dup

0.500

0.070

-

-

 Age + sex + ASD

-

-

-

0.033

0.643

Del

0.782

<0.001

-

-

      

Dup

0.811

0.001

-

-

 Age + sex + PSY

-

-

-

0.558

0.054

Del

0.648

<0.001

-

-

      

Dup

0.743

<0.001

-

-

Longitudinal

β

p-value

Group

β

p-value

Group

β

q-value

β

p-value

 Age + sex

−0.074

0.754

 

0.213

<0.001

Del

0.747

<0.001

−0.122

0.601

      

Dup

0.747

<0.001

−0.325

0.289

 Age+ sex + attention

−0.214

0.276

-

0.222

0.003

Del

0.546

0.005

0.023

0.927

      

Dup

0.611

0.010

−0.273

0.421

 Age+ sex + medication

−0.074

0.690

Antipsychotic

0.537

0.013

Del

0.600

<0.001

−0.106

0.654

   

Mood Stabilizer

0.321

0.109

-

-

-

-

-

   

Stimulant

0.110

0.657

-

-

-

-

-

   

Other

0.430

0.099

Dup

0.662

<0.001

−0.363

0.261

 Age + sex + IQa

−0.196

0.312

-

−0.102

0.299

Del

0.574

0.011

−0.130

0.595

      

Dup

0.522

0.056

-

-

 Age + sex + ASD

−0.061

0.740

-

−0.048

0.387

Del

0.669

<0.001

−0.085

0.725

      

Dup

0.647

0.005

−0.312

0.314

 Age + sex + PSY

−0.055

0.767

-

0.305

0.118

Del

0.703

<0.001

−0.120

0.615

      

Dup

0.748

<0.001

−0.381

0.229

  1. aInsufficient longitudinal IQ data in 22q11.2 duplication group