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Fig. 5 | Journal of Neurodevelopmental Disorders

Fig. 5

From: Baclofen-associated neurophysiologic target engagement across species in fragile X syndrome

Fig. 5

Effect of 2.5 mg/kg RBAC on auditory chirp in Fmr1 KO mice. For each cortical region, the left panel shows the averaged inter-trial phase coherence (ITPC or phase locking factor) before vehicle treatment (Pre), the middle panel shows the averaged ITPC after vehicle treatment (Post) and the right panel shows Post–Pre. Significant increases in ITPC in Post compared to Pre are shown in black-outlined areas. Red areas in the right panels (Post–Pre) represent positive ITPC differences and blue areas represent negative ITPC differences

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