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Table 2 Auditory event-related potentials in rodent models of ASD. Entries are in bold if they are supported by more than one study or represent the result of the majority of the studies using that model (if there is no majority, no result is in bold). Numbers in subscript brackets refer to the relevant papers from the literature search, as numbered in Supplementary Table 1. Asterisks indicate cases where all of the studies contributing to that result were conducted in anaesthetised animals. Models are listed in alphabetical order

From: Auditory processing in rodent models of autism: a systematic review

Measure

Models increased compared to WT

Models unchanged compared to WT

Models decreased compared to WT

P1 amplitude

Fmr1(30)

Fmr1(32, 37, 73, 83), Mecp2(26, 35), NR1(69)

15q13.3(31)

N1 amplitude

Cntnap2*(71), Fmr1(30, 32, 37, 83), Mecp2(16, 26, 35), MGluR5(4), VPA*(13)

15q13.3(31), Fmr1(37, 83), NR1(69), Pcdh10(59)

Ehmt1(9), Fmr1*(14), VPA*(13)

P2 amplitude

Cntnap2*(71), Fmr1(30), Mecp2(26)

Fmr1(30, 32, 37, 83), Mecp2(26, 35)

Fmr1*(14), Mecp2*(16), MGluR5(4), VPA*(13)

P1 latency

Fmr1(37), Mecp2(26)

Fmr1(30, 32, 83), Mecp2(26, 35), NR1(69)

 

N1 latency

Cntnap2*(71), Fmr1(37, 83), Mecp2(16, 26), NR1(22, 69), VPA(23)

Fmr1(30, 32, 37, 40, 83), Mecp2(35), Pcdh10(59)

 

P2 latency

Cntnap2*(71), Fmr1(30), Mecp2(16, 26, 35)

Mecp2(26), Fmr1(30, 37, 83)

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