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Fig. 2 | Journal of Neurodevelopmental Disorders

Fig. 2

From: Cortical and subcortical morphological alteration in Angelman syndrome

Fig. 2

VBM and SBM analyses of seizure—non-seizure cohort showing by T statistic maps. (reduced in blue and increased in red). VBM analysis showed significantly reduced gray matter volume in bilateral caudate in AS-Se compared with AS-NSe groups (a). The results were thresholded at uncorrected p < 0.005 with clusters less than 100 voxels excluded. The SBM analysis showed significantly reduced CTH in the right superior frontal gyrus, left orbitofrontal gyrus, bilateral insula, and left precuneus (b) and significantly increased LGI in the right precuneus in the AS-Se group (c). The results were thresholded at uncorrected p < 0.005 and clusters’ size > 100 vertexes. AS Angelman syndrome, HC health controls, Se seizure, NSe non-seizure, CTH cortical thickness, LGI local gyrification index

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