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Table 3 Child Behavior Checklist scores in the XYY syndrome

From: Deep phenotypic analysis of psychiatric features in genetically defined cohorts: application to XYY syndrome

CBCL scale name

T-score

Linear association with FSIQ

Linear association with VABC

Linear association with CSQ

% in borderline or clinical range

Difference between prenatally vs. postnatally diagnosed XYY

% prenatally diagnosed XYY in borderline or clinical range

 

Full

Abbreviated

Mean

Sd

p (vs. null of 50)

Std. beta

p

Std. beta

p

Std. beta

p

 

std. beta

p

  

Anxious/depressed

AnxDep

58.8

7.72

 < 0.00001

 − 0.17

0.270

 − 0.36

0.0105

0.27

0.1086

25

0.24

0.2378

 

8

Withdrawndepressed

WithDep

62.2

10.2

 < 0.00001

 − 0.17

0.148

-0.37

0.0004

0.22

0.0872

34

0.42

0.1131

 

24

Somatic complaints

Somatic

61.2

8.06

 < 0.00001

 − 0.41

0.004

 − 0.29

0.0331

0.23

0.1544

30

0.63

0.0019

 

12

Social problems

Social

65.3

9.39

 < 0.00001

 − 0.46

0.002

 − 0.52

0.0000

0.59

0.0000

41

0.77

0.0051

 

28

Though problems

Thought

63.9

8.25

 < 0.00001

 − 0.29

0.048

 − 0.48

0.0003

0.52

0.0006

42

0.69

0.0013

 

16

Attention problems

Attention

67.2

8.01

 < 0.00001

 − 0.28

0.052

 − 0.47

0.0004

0.62

0.0000

64

0.61

0.0029

 

44

Rule breaking

RuleBreak

59.9

9.72

 < 0.00001

 − 0.07

0.563

 − 0.27

0.0194

0.66

0.0000

25

0.20

0.4558

 

24

Aggressive behavior

Aggressive

61.6

11

 < 0.00001

 − 0.16

0.142

 − 0.33

0.0008

0.65

0.0000

34

0.41

0.1557

 

28

Internalizing

Int

61.4

8.29

 < 0.00001

 − 0.32

0.021

 − 0.51

0.0000

0.39

0.0107

58

0.56

0.0090

 

48

Externalizing

Ext

59.4

12.3

 < 0.00001

 − 0.06

0.501

 − 0.25

0.0045

0.59

0.0000

50

0.44

0.1752

 

44

Total problems

Totprob

64.4

8.67

 < 0.00001

 − 0.32

0.015

 − 0.56

0.0000

0.81

0.0000

69

0.70

0.0013

 

52

  1. Score distributions are given for each subscale, both broadband scales and the total problems scale. We also show the standardized regression coefficient and associated p-values for regressions using interindividual score variation in each CBCL scale to model variation in Full-Scale IQ (FSIQ), Vineland Adaptive Behavior Composite Scale (VABC), and the caregiver strain questionnaire (CSQ). Finally, we report the following: the percentage of all 64 individuals with CBCL scale scores in the borderline or clinical range, the regression effect size and p-value for prenatally vs. postnatally diagnosed subgroups of the full XYY cohort, and the percentage of all 25 prenatally diagnoses XYY individuals with CBCL scale scores in the borderline or clinical range. Bold text denotes statistical tests that survive Bonferroni adjustment for multiple comparisons (adjusted p-value = 0.05/11 = 0.0045)